| Description | The Aquatic Toxicity Classification by ECOSAR profiler consists of molecular definitions developed by LMC and OECD to mimic the structural definitions of chemical classes within the U.S. Environmental Protection Agency’s Ecological Structure-Activity Program (ECOSAR™). ECOSAR™ contains a library of class-based SARs for predicting aquatic toxicity, overlaid with an expert decision tree based on expert rules for selecting the appropriate chemical class for evaluation of the compound. ECOSAR™ is currently programmed to identify 118 chemical classes. The profiler is introduced for chemical categorization purposes using the class definitions from ECOSAR™ and not for predicting quantitative toxicity values. |
| Website | https://www.epa.gov/tsca-screening-tools/ecological-structure-activity-relationships-ecosar-predictive-model |
| Author(s) | LMC Bourgas, Bulgaria and the U.S. EPA Office of Pollution Prevention and Toxics |
| Donator | United States Environmental Protection Agency (EPA), USA |
| Disclaimer | The designation of a chemical into an ECOSAR™ class does not necessarily convey an aquatic hazard. Once placed in a class, factors such as molecular size and shape, solubility, lipophilicity, attached sub-units, ect. will affect the toxicity potential of a chemical. To determine quantitative toxicity values for a chemical, the users are encouraged to run the U.S. EPA’s ECOSAR™ model as a stand alone program. ECOSAR™ has been peer reviewed, runs on a Windows® PC, and is being released by the U.S. EPA at no cost, to be available to any researcher or organization wishing to evaluate the toxicity potential of chemicals. The ECOSAR™ program can be accessed through the OECD QSAR Toolbox’s "Filling Data Gaps" page or downloaded from the U.S. EPA website at: https://www.epa.gov/tsca-screening-tools/ecological-structure-activity-relationships-ecosar-predictive-model |
| Version | 1.11 |
| Adopted | Toolbox 2.1,February 2011 |