ECHA REACH

Description The ECHA REACH database (formerly the ECHA CHEM database) includes public and disseminated information on chemical substances manufactured or imported in Europe. The information originates from the registration dossiers, submitted by companies to the European Chemicals Agency (ECHA) in the framework of Regulation (EC) No 1907/2006 (the REACH Regulation). The amount of information available for each substance depends on the information requirements specified under REACH - for example, the higher the production volume of the substance, the more information the companies need to provide. Please be aware that ECHA does not verify the information before dissemination; therefore, no guarantees and/or warranties can be given as to its quality.
Website https://echa.europa.eu/information-on-chemicals/registered-substances?p_p_id=dissregisteredsubstances_WAR_dissregsubsportlet&p_p_lifecycle=1&p_p_state=normal&p_p_mode=view&_dissregisteredsubstances_WAR_dissregsubsportlet_javax.portlet.action=dissRegisteredSubstancesAction
Donator European Chemicals Agency (ECHA)
Disclaimer ECHA REACH database contains information on registered chemical substances provided by companies in accordance with the requirements of REACH Regulation (EC) No 1907/2006. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. ECHA cannot guarantee the correctness of the information in the databases and the REACH Regulation does not permit it to make modifications to the data provided by registrants. The European Chemicals Agency maintains the database to ensure public access to information about registered chemical substances. ECHA’s goal is to keep this information timely and accurate. If errors are brought to ECHA’s attention, we will try to correct them. However, ECHA accepts no responsibility or liability whatsoever with regard to the information provided in the database, and the information does not necessarily reflect the official opinion of the Agency. Use the information with care. Reproduction or further distribution of the information may be subject to copyright laws and might require the permission of the owner of that information. Potential registrants are reminded that pursuant to Article 10 of the REACH Regulation, the potential registrant has to be in legitimate possession of the full study report or to have permission to refer to the full study report for the purpose of registration. Certain data from ECHA REACH can be exported, namely the REACH Study Results. Exporting this data from ECHA REACH or their inclusion in the Toolbox reports is possible only after downloading the related extension from the Toolbox repository (available https://repository.qsartoolbox.org). Note that the use of the REACH Study Results is subject to specific terms and conditions (available here: https://iuclid6.echa.europa.eu/documents/21812392/21895143/reach_study_results-terms_and_conditions_en.pdf), which you have to accept prior to downloading the ECHA REACH extension. Before using the data, you are advised to read carefully the terms and conditions which apply mutatis mutandis.
Version12.2022
Substances80424
TB representation Test materials65860
TB representation Dossiers/Substances24359
Adopted2012
EndpointsBMD: dose level: NOAEL NOAEC conc. level: LOEC Other Endpoint NOEC BMCL10 LOEL LOAEL NOEL LOAEC Other conjunctivae score percent tissue viability mean percent tissue viability erythema score edema score fluorescein retention score Skin Irritation/Corrosion TEER value (Transepithelial Electrical Resistance) transcutaneous electrical resistance (in kΩ) fluorescein leakage corneal swelling cornea opacity score morphological effects percent corneal swelling dye content (µg/disc) in vitro irritation score maximum mean total score (MMTS) overall irritation score % tissue viability chemosis score primary dermal irritation index (PDII) penetration time (in minutes) histopathological observations iris score Eye Irritation BMDL10 BMCL05 NOELR EC90 EL20 IC50 EC100 EC20 EC10 LC100 EC50 LC0 LL0 IC10 LC10 EC80 LC50 LC25 IC25 EL50 EL10 LOELR EC25 EL100 EC0 EL0 LL50 LL100 LL10 IC100 LC90 flammability flammable liquids: obsolete as covered by section 'Flash point' pyrophoric liquids flammability, other self-heating substances / mixtures flammable gases flammable solids substances / mixtures which in contact with water emit flammable gases pyrophoric solids % degradation (CH4 evolution) not specified % degradation (DOC removal) half-life in days (QSAR/QSPR) % degradation (test mat. analysis) % degradation (radiochem. meas.) % degradation (O2 consumption) % degradation (ThOD) calculated rating of total degradation time (QSAR/QSPR) % degradation (TOC removal) % degradation (CO2 evolution) % degradation (inorg. C analysis) distribution modelling DT50 inorg. C analysis TOC removal radiochem. meas. O2 consumption CO2 evolution test mat. analysis LCLo LC50 cut-off discriminating dose LD50 LDLo LD0 LD100 discriminating conc. NOED RFI CD86>200 [442E] IC30 [442D] lysine depletion EC 1.5 [442D] CV75 [442D and 442E] Imax [442D] RFI CD54>150 [442E] ECt EC200, CD54 [442E] mean lysine depletion IC50 [442D] CV70 [442E] Respiratory sensitization SI EC150, CD86 [442E] Skin sensitisation EC3 cysteine depletion mean cystein depletion DOC removal CH4 evolution explosiveness, other explosive properties of explosives explosiveness gases under pressure log Kd log Koc Koc Kd dynamic viscosity (in mPa s) kinematic viscosity (in mm²/s) flash point flash point, other flash point of flammable liquids ER10 ER25 ER50 LR50 D10 D25 D90 D95 D99 D50 D75 BSAF BCF auto-ignition temperature, other relative self-ignition temperature (solids) auto-ignition temperature (gases) auto-flammability auto-ignition temperature (liquids) sensitiveness to impact: impact energy (J) thermal sensitivity - Koenen test: limiting diameter (mm) sensitiveness to friction: friction load (N) bulk density density, other relative density tap density density in vitro transformation study in mammalian cells in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration in vivo mammalian somatic and germ cell study: gene mutation in vitro / micronucleus study in vivo mammalian germ cell study: gene mutation in vitro gene mutation study in mammalian cells in vivo mammalian somatic cell study: gene mutation in vitro DNA damage and/or repair study in vivo mammalian germ cell study: cytogenicity / chromosome aberration genetic toxicity in vitro genetic toxicity in vivo Gene mutation genetic toxicity in vitro, other in vitro chromosome aberration study in mammalian cells in vivo mammalian cell study: DNA damage and/or repair in vivo insect germ cell study: gene mutation in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus genetic toxicity in vivo, other Rate constant T25 Hydrolysis rate constant blood/placenta barrier Absorption rate - oral secretion via gastric mucosa blood/brain barrier Absorption rate - inhalation Bioaccumulation potential oxidising gases oxidising liquids oxidising properties oxidising solids oxidising properties, other acidity / alkalinity pH boiling point transformation / dissolution of metals and inorganic metal compounds water solubility BAF BMF amount percentage Absorption rate - dermal rate dissociation constant Henry's law constant stability in organic solvents and identity of relevant degradation products oxidation reduction potential corrosive to metals solubility in organic solvents / fat solubility vapour pressure partition coefficient melting point/freezing point monitoring data surface tension
Endpoint pathsHuman Health Hazards#Developmental Toxicity / Teratogenicity Human Health Hazards#Irritation / Corrosion Human Health Hazards#Repeated Dose Toxicity Ecotoxicological Information#Aquatic Toxicity Physical Chemical Properties#Flammability Environmental Fate and Transport#Biodegradation#in water: screening tests Environmental Fate and Transport#Transport and Distribution#Distribution modelling Environmental Fate and Transport#Biodegradation#in soil Human Health Hazards#Acute Toxicity Ecotoxicological Information#Sediment Toxicity Human Health Hazards#Sensitisation Environmental Fate and Transport#Biodegradation#in water and sediment: simulation tests Physical Chemical Properties#Explosive properties Physical Chemical Properties#Gases under pressure Environmental Fate and Transport#Transport and Distribution#Adsorption/desorption Physical Chemical Properties#Viscosity Physical Chemical Properties#Flash point Ecotoxicological Information#Terrestrial Toxicity Human Health Hazards#Specific investigations#Endocrine disrupter Physical Chemical Properties#Particle size Environmental Fate and Transport#Bioaccumulation#terrestrial Human Health Hazards#Toxicity to Reproduction Physical Chemical Properties#Autoflammability / Self-ignition temperature Physical Chemical Properties#Self-reactive substances Physical Chemical Properties#Density Human Health Hazards#Genetic Toxicity Human Health Hazards#Immunotoxicity Environmental Fate and Transport#Stability#Photodegradation#in water Human Health Hazards#Carcinogenicity Human Health Hazards#Neurotoxicity Environmental Fate and Transport#Stability#Hydrolysis Human Health Hazards#Toxicokinetics, Metabolism and Distribution#Basic toxicokinetics Physical Chemical Properties#Oxidising properties Physical Chemical Properties#pH Environmental Fate and Transport#Stability#Photodegradation#in air Physical Chemical Properties#Boiling point Physical Chemical Properties#Water solubility Environmental Fate and Transport#Bioaccumulation#aquatic / sediment Human Health Hazards#Toxicokinetics, Metabolism and Distribution#Dermal absorption Physical Chemical Properties#Dissociation Constant (pKa) Environmental Fate and Transport#Transport and Distribution#Henry's Law constant (H) Physical Chemical Properties#Stability in organic solvents and identity of relevant degradation products Environmental Fate and Transport#Stability#Photodegradation#in soil Physical Chemical Properties#Oxidation reduction potential Physical Chemical Properties#Corrosivity to metals Physical Chemical Properties#Solubility in organic solvents / fat solubility Physical Chemical Properties#Vapour pressure Physical Chemical Properties#Partition Coefficient:#N-Octanol/Water Physical Chemical Properties#Melting / freezing point Environmental Fate and Transport#Transport and Distribution#Monitoring data Physical Chemical Properties#Surface tension
Data1143434